safety and satisfaction of treatment with carboxytherapy
Purpose: to evaluate effectiveness, safety and satisfaction of treatment with carboxytherapy in dark eye circles.
Methods: This trial was conducted on 20 eligible Iranian patients with symmetric dark eye circles who received carboxytherapy as injection of once-weekly/4-session intradermally 10-20 cc CO2 gas, rate: 20 cc/minute, angle: 15 degree, maximum 1 minute (usually few seconds). Patients followed 1 month later after last session.
The primary outcome measure was changes of ΔE (differences between pigmentation at orbital and extra-orbital skin), before and after trial.
Results: The effect of carboxytherapy on reduction of periorbital darkness based on ΔE was statistically significantly in all three parts of treatment areas (in lateral, middle and medial parts of orbit with P-value of 0.002, 0.001 and 0.001, respectively) and
acceptable in terms of patients’ satisfaction. The percentage of responsiveness to carboxytherapy in all three areas was about 20%. Patients' satisfaction was higher than the delta E changes with no significant linear relationship (P-value = 0.084).
Conclusion: Carboxytherapy therapy is an effective therapeutic option for dark eye circles with good safety profile and patients’ satisfaction.
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